Robin J C, Suh O W, Ambrus J L
Steroids. 1982 Aug;40(2):125-32. doi: 10.1016/0039-128x(82)90026-5.
Total body neutron activation analysis was employed to measure total calcium in C3H/St (Ha) female mice. Ninety-nine percent of total body calcium is in bone and loss of calcium was used as an index of osteoporosis. Heparin (500 U/kg B.I.D.) treatment for three months resulted in significant osteoporosis. 17 beta-Hydroxy-4-estren-3-one 17-decanoate 1.5 mg/kg or 4 mg/kg twice monthly prevented this heparin accelerated osteoporosis. The results suggest that 17 beta-hydroxy-4-estren-3-one 17-decanoate may be capable of preventing bone loss and partially increasing bone mass in patients exposed to osteoporosis inducing regimens.
采用全身中子活化分析法测量C3H/St（Ha）雌性小鼠的总钙含量。全身钙的99%存在于骨骼中，钙的流失被用作骨质疏松症的指标。肝素（500 U/kg，每日两次）治疗三个月导致明显的骨质疏松症。17β-羟基-4-雌烯-3-酮17-癸酸酯以1.5 mg/kg或4 mg/kg的剂量每月两次给药可预防这种肝素加速的骨质疏松症。结果表明，17β-羟基-4-雌烯-3-酮17-癸酸酯可能能够预防接受诱发骨质疏松症方案治疗的患者的骨质流失并部分增加骨量。
