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通过给小鼠口服念珠菌产生的全身性念珠菌病。

Systemic candidiasis produced by oral Candida administration in mice.

作者信息

Umenai T

出版信息

Tohoku J Exp Med. 1978 Oct;126(2):173-5. doi: 10.1620/tjem.126.173.

DOI:10.1620/tjem.126.173
PMID:715766
Abstract

Systemic Candida infection from the gastrointestinal tract was examined in mice. Candida albicans was undetectable in the blood, lungs, spleen, liver or kidneys of mice 24 hr after oral Candida administration even under condition of severe damage to the host defence system, but became detectable in the liver and kidneys of mice when they received combined treatment of antibiotics, x-ray irradiation and dexamethasone 3 and 5 days after oral Candida administration.

摘要

在小鼠中研究了来自胃肠道的全身性念珠菌感染。口服念珠菌后24小时,即使在宿主防御系统严重受损的情况下,小鼠的血液、肺、脾、肝或肾中也未检测到白色念珠菌,但在口服念珠菌后3天和5天接受抗生素、X射线照射和地塞米松联合治疗时,小鼠的肝脏和肾脏中可检测到白色念珠菌。

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1
Systemic candidiasis produced by oral Candida administration in mice.通过给小鼠口服念珠菌产生的全身性念珠菌病。
Tohoku J Exp Med. 1978 Oct;126(2):173-5. doi: 10.1620/tjem.126.173.
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Systemic candidiasis from Candida albicans colonizing the gastrointestinal tract of mice.白色念珠菌在小鼠胃肠道定殖导致的全身性念珠菌病。
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引用本文的文献

1
Persistence and spread of Candida albicans after intragastric inoculation of infant mice.白色念珠菌在幼鼠胃内接种后的持续性和传播
Infect Immun. 1981 Feb;31(2):783-91. doi: 10.1128/iai.31.2.783-791.1981.
2
Pathogenicity of Candida tropicalis and Candida albicans after gastrointestinal inoculation in mice.热带念珠菌和白色念珠菌经胃肠道接种小鼠后的致病性。
Infect Immun. 1980 Aug;29(2):808-13. doi: 10.1128/iai.29.2.808-813.1980.
3
Differences in virulence of clinical isolates of Candida tropicalis and Candida albicans in mice.热带念珠菌和白色念珠菌临床分离株在小鼠体内的毒力差异。
Infect Immun. 1982 Aug;37(2):833-6. doi: 10.1128/iai.37.2.833-836.1982.
4
A model of sustained gastrointestinal colonization by Candida albicans in healthy adult mice.白色念珠菌在健康成年小鼠胃肠道持续定殖的模型。
Infect Immun. 1990 Jun;58(6):1514-7. doi: 10.1128/iai.58.6.1514-1517.1990.
5
Systemic candidiasis from Candida albicans colonizing the gastrointestinal tract of mice.白色念珠菌在小鼠胃肠道定殖导致的全身性念珠菌病。
Experientia. 1979 Oct 15;35(10):1331-2. doi: 10.1007/BF01963990.
6
Systemic and gastrointestinal candidiasis of infant mice after intragastric challenge.幼鼠经胃内攻击后的全身性和胃肠道念珠菌病
Infect Immun. 1979 Aug;25(2):702-7. doi: 10.1128/iai.25.2.702-707.1979.