Umenai T, Konno S, Ishida N
Experientia. 1979 Oct 15;35(10):1331-2. doi: 10.1007/BF01963990.
Reproducible induction of systemic Candida infection was achieved by treating mice in which Candida colonization had been established in the gastrointestional tract by aminobenzylpenicillin treatment. Systemic candidiasis was induced in these mice by X-ray irradiation followed by immunosuppressive doses of dexamethasone or X-ray irradiation followed by immunosuppressive doses of trypan blue. Macrophages seem to play an important role in thie systemic infection.
通过对经氨基苄青霉素处理已在胃肠道建立念珠菌定植的小鼠进行治疗，实现了系统性念珠菌感染的可重复性诱导。对这些小鼠进行X射线照射，随后给予免疫抑制剂量的地塞米松，或进行X射线照射，随后给予免疫抑制剂量的台盼蓝，从而诱发系统性念珠菌病。巨噬细胞似乎在这种全身感染中发挥重要作用。
