Tibboel D, van der Kamp A W, Molenaar J C
Z Kinderchir. 1982 Oct;37(2):62-6. doi: 10.1055/s-2008-1059818.
The effect of an experimentally induced intestinal perforation was studied in chick embryos. In 5 different groups of embryos a perforation was induced at 5 different developmental stages, while an equal number of sham operations was carried out for each stage. The results demonstrate that the effect of an intestinal perforation is determined by the developmental stage at which this perforation occurs. There was an inverse relationship between the developmental stage at which the perforation was induced and the remaining traces of the perforation site at the end of incubation. A perforation induced at an earlier developmental stage was more likely to lead to intestinal atresia coupled with only microscopic signs of meconium peritonitis. The severity of the adhesions increased concurrently with the developmental stage.
在鸡胚中研究了实验诱导的肠穿孔的影响。在5组不同的胚胎中，在5个不同的发育阶段诱导穿孔，同时在每个阶段进行相同数量的假手术。结果表明，肠穿孔的影响取决于穿孔发生时的发育阶段。诱导穿孔的发育阶段与孵化结束时穿孔部位的残留痕迹之间存在反比关系。在较早发育阶段诱导的穿孔更有可能导致肠闭锁，同时仅伴有胎粪性腹膜炎的微观迹象。粘连的严重程度随着发育阶段的增加而增加。
