Tibboel D, Gaillard J L, Molenaar J C
Hum Pathol. 1986 Apr;17(4):411-6. doi: 10.1016/s0046-8177(86)80466-x.
The etiology of bowel perforations leading to meconium peritonitis was investigated in an attempt to explain the occurrence of such perforations in the absence of primary intestinal obstruction. Bowel specimens from 22 patients who had presented with meconium peritonitis during a 15-year period, as well as specimens from five patients with intestinal atresia without associated meconium peritonitis, were re-evaluated microscopically. An extensive review of the literature concerning meconium peritonitis, involving 1,084 patients, was compared with the results of a retrospective study of 69 patients from The Netherlands. In approximately 50 per cent of these cases there was no detectable primary cause of the bowel perforation. The pathologic findings, in combination with earlier experimental studies, indicate that vascular insufficiency may result in bowel wall perforation without prior intestinal obstruction. It is suggested that temporary decrease of mesenteric blood flow could lead to intestinal atresia and/or meconium peritonitis.
为了解释在无原发性肠梗阻情况下肠穿孔导致胎粪性腹膜炎的发生原因，对其病因进行了调查。对15年间出现胎粪性腹膜炎的22例患者的肠标本，以及5例无相关胎粪性腹膜炎的肠闭锁患者的标本进行了显微镜下重新评估。将涉及1084例患者的关于胎粪性腹膜炎的广泛文献综述与来自荷兰的69例患者的回顾性研究结果进行了比较。在这些病例中，约50%未发现肠穿孔的可检测原发性病因。病理结果与早期实验研究相结合表明，血管功能不全可能导致肠壁穿孔而无先前的肠梗阻。提示肠系膜血流的暂时减少可能导致肠闭锁和/或胎粪性腹膜炎。
