[Morphological analysis of the rat organs after massive blood substitution with perfluorotributylamine emulsion].

Four--eight months after 60--70% substitution of the blood of rats with perfluorotributyl amine emulsion (PFTBA) multiple separate and confluent vacuoles containing PFTBA were detected in cells of the macrophage system in the liver, spleen, lymph nodes, bone marrow, and reticular layer of the adrenal cortex. The macrophages containing perfluorocarbon had a low functional activity confirmed histochemically. Accumulations of macrophages at remote intervals after blood substitution are replaced by polymorphocellular granulomas. The morphofunctional properties of parenchymatous cells of the organs outside of these accumulations as well as other organs not accumulating PFTBA remain normal.