雌激素对鸽主动脉中胆固醇酯合成酶和胆固醇酯水解酶活性的影响。

Effect of estrogens on the acitivities of cholesteryl ester synthetase and cholesteryl ester hydrolases in pigeon aorta.

作者信息

Subbiah M T

出版信息

Steroids. 1977 Aug;30(2):259-65. doi: 10.1016/0039-128x(77)90086-1.

PMID:201055

Abstract

This study is the first to report the effect of conjugated equine estrogens on the acitivity of cholesteryl ester synthetase and cholesteryl ester hydrolases in the aorta. In spontaneously atherosclerosis-susceptible White Carneau pigeons, estrogens significantly decreased (P less 0.01) the activity of cholesteryl ester synthetase and increased (P less than 0.01) the cholesteryl ester hydrolase activity in the microsomal fraction of the aorta. There was no effect on the cholesteryl ester hydrolase activity in the supernatant fraction. The inhibition of cholesteryl ester synthesis and the stimulation of cholesteryl ester hydrolase might be responsible for the decreased content of cholesteryl esters noted in pigeon aorta after estrogen treatment.

摘要

本研究首次报道了共轭马雌激素对主动脉中胆固醇酯合成酶和胆固醇酯水解酶活性的影响。在自发性易患动脉粥样硬化的白卡诺鸽中，雌激素显著降低了（P<0.01）主动脉微粒体部分胆固醇酯合成酶的活性，并增加了（P<0.01）胆固醇酯水解酶的活性。对上清液部分的胆固醇酯水解酶活性没有影响。胆固醇酯合成的抑制和胆固醇酯水解酶的刺激可能是雌激素处理后鸽主动脉中胆固醇酯含量降低的原因。