Simultaneous determination of terbutaline and salbutamol in plasma by selected ion monitoring.
作者信息
Lindberg C, Jönsson S
出版信息
Biomed Mass Spectrom. 1982 Nov;9(11):493-43. doi: 10.1002/bms.1200091107.
PMID:7159684
Abstract
We describe a method for simultaneous determination of terbutaline and salbutamol in plasma, based on gas chromatography chemical ionization mass spectrometry. Deuterium labelled terbutaline was used as internal standard for both drugs. The method has been used for the analysis of plasma samples obtained from asthmatic patients. The coefficient of variation at 0.3 ng ml-1 was 4.6% for terbutaline and 5.3% for salbutamol with a sample volume of 4 ml. The recovery of both drugs was greater than 80%.
摘要
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