在人类白细胞中发现的一种己糖激酶（HK III）形式的基因决定多态性。

Genetically determined polymorphism of a form of hexokinase, HK III, found in human leucocytes.

Povey S, Corney G, Harris H

Ann Hum Genet. 1975 May;38(4):407-15. doi: 10.1111/j.1469-1809.1975.tb00630.x.

Abstract

A form of hexokinase which appears to correspond to HK III, seen in liver, spleen and lung, has been identified in human polymorphonuclear leucocytes. HK III activity has not been demonstrated in lymphocytes, permanent lymphoblastoid cell lines or in cultured fibroblasts. 2. In fresh leucocyte preparations HK III usually appeared as a single band, but in extracts of post-mortem tissues multibanded patterns were seen. Leucocyte preparations also give multi-banded patterns after storage for more than a few hours. 3. In certain individuals the HK III showed a two-banded pattern even in fresh preparations. Repeat samples and family studies suggested that this pattern was genetically determined and represented a heterozygote for a common allele HK1III and a less common variant HK2III. Out of a total of 330 English people successfully tested 10 probable heterozygotes were found. 4. It is suggested that HK III may be a monomeric enzyme whose genetic determination is independent of that of the other main forms of hexokinase.

摘要

在人类多形核白细胞中已鉴定出一种己糖激酶形式，它似乎与在肝脏、脾脏和肺中发现的HK III相对应。在淋巴细胞、永久性淋巴母细胞系或培养的成纤维细胞中未检测到HK III活性。2. 在新鲜白细胞制剂中，HK III通常表现为单一条带，但在死后组织提取物中可见多条带模式。白细胞制剂在储存数小时以上后也会出现多条带模式。3. 在某些个体中，即使在新鲜制剂中，HK III也呈现两条带模式。重复样本和家族研究表明，这种模式是由基因决定的，代表了常见等位基因HK1III和较不常见变体HK2III的杂合子。在总共330名成功检测的英国人中，发现了10名可能的杂合子。4. 有人提出，HK III可能是一种单体酶，其基因决定与其他主要形式的己糖激酶无关。