Richardson J S, Chiu E K
Pharmacol Biochem Behav. 1982 Dec;17(6):1221-3. doi: 10.1016/0091-3057(82)90124-1.
The cardiovascular effects of the tricyclic anti-depressant amitriptyline, a monoamine uptake inhibitor, and iprindole and trazodone, two novel anti-depressants of unknown mechanism, were monitored in urethane anesthetized rats following intravenous (IV) or intracerebroventricular (IVT) injection. Amitriptyline (2 mg IV or 0.25 mg IVT) produced hypotension that might reflect an action of norepinephrine on the anterior hypothalamus. Iprindole (2 mg IV) produced hypertension and (0.25 mg IVT) tachycardia that is consistent with a partial beta-agonist mechanism. Trazodone (1 mg IV or 0.25 mg IVT) produced hypotension and bradycardia that is consistent with the activation of noradrenergic neurons in the anterior hypothalamus perhaps as a result of trazodone acting on presynaptic alpha 2 receptors or on presynaptic serotonin receptors to increase the release of norepinephrine. All three of these anti-depressants have the potential to precipitate cardiovascular complications, particularly in patients with pre-existing cardiovascular abnormalities.
在给乌拉坦麻醉的大鼠静脉注射（IV）或脑室内注射（IVT）后，监测了三环类抗抑郁药阿米替林（一种单胺摄取抑制剂）、异吲哚酮和曲唑酮（两种作用机制不明的新型抗抑郁药）的心血管效应。阿米替林（静脉注射2毫克或脑室内注射0.25毫克）导致低血压，这可能反映了去甲肾上腺素对下丘脑前部的作用。异吲哚酮（静脉注射2毫克）导致高血压，（脑室内注射0.25毫克）导致心动过速，这与部分β激动剂机制一致。曲唑酮（静脉注射1毫克或脑室内注射0.25毫克）导致低血压和心动过缓，这与下丘脑前部去甲肾上腺素能神经元的激活一致，可能是由于曲唑酮作用于突触前α2受体或突触前5-羟色胺受体以增加去甲肾上腺素的释放。所有这三种抗抑郁药都有可能引发心血管并发症，尤其是在已有心血管异常的患者中。
