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通过海马体电刺激增强潜伏抑制

Augmentation of latent inhibition by electrical stimulation of hippocampus.

作者信息

Salafia W R, Allan A M

出版信息

Physiol Behav. 1982 Dec;29(6):1125-30. doi: 10.1016/0031-9384(82)90308-0.

DOI:10.1016/0031-9384(82)90308-0
PMID:7163391
Abstract

The effects of low-level hippocampal stimulation on the development of latent inhibition were investigated employing classical conditioning of the nictitating membrane response of rabbits. Four groups were given either (a) no preexposure of the to-be-CS, (b) preexposure, (c) preexposure overlapped by hippocampal stimulation or (d) preexposure overlapped by cortical stimulation, followed by 300 conditioning trials for each group. After conditioning, the hippocampal group was divided into two groups designated HS-1 and HS-2 by means of a post-hoc test for stimulation effects. Conditioning was found to be retarded in all three preexposed groups, with significantly greater retardation (augmentation of latent inhibition) in Group HS-2. The results support a general conception that the hippocampal stimulation produced its effects through the modulation of sensory input.

摘要

采用兔瞬膜反应经典条件反射,研究了海马低水平刺激对潜伏抑制发展的影响。四组分别接受:(a)对即将成为条件刺激物(CS)的刺激无预暴露;(b)预暴露;(c)预暴露同时进行海马刺激;或(d)预暴露同时进行皮层刺激,随后每组进行300次条件反射试验。条件反射后,通过刺激效应的事后检验,将海马组分为两组,分别命名为HS-1和HS-2。在所有三个预暴露组中,条件反射均受到延迟,HS-2组的延迟明显更大(潜伏抑制增强)。结果支持了一个普遍观点,即海马刺激通过调节感觉输入产生其效应。

相似文献

1
Augmentation of latent inhibition by electrical stimulation of hippocampus.通过海马体电刺激增强潜伏抑制
Physiol Behav. 1982 Dec;29(6):1125-30. doi: 10.1016/0031-9384(82)90308-0.
2
Attenuation of latent inhibition by electrical stimulation of hippocampus.海马体电刺激对潜伏抑制的减弱作用。
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Effects of hippocampal manipulations on the classically conditioned nictitating membrane response: simulations by an attentional-associative model.海马体操作对经典条件反射性瞬膜反应的影响:基于注意力-联想模型的模拟
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Latent inhibition and stimulus generalization of the classically conditioned nictitating membrane response in rabbits (Oryctolagus cuniculus) following dorsal hippocampal ablation.背侧海马切除后家兔(穴兔)经典条件反射性瞬膜反应的潜伏抑制和刺激泛化
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Role of the hippocampus in blocking and conditioned inhibition of the rabbit's nictitating membrane response.海马体在兔瞬膜反应的阻断和条件性抑制中的作用。
J Comp Physiol Psychol. 1977 Apr;91(2):407-17. doi: 10.1037/h0077330.
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Selective hippocampal lesions abolish the contextual specificity of latent inhibition and conditioning.选择性海马损伤消除了潜伏抑制和条件作用的情境特异性。
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Ontogeny of context-specific latent inhibition of conditioned fear: implications for configural associations theory and hippocampal formation development.条件性恐惧的情境特异性潜伏抑制的个体发生:对构型联想理论和海马结构发育的启示
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