Anderson D M, Ashby P, Busuttil A, Eastwood M A, Hobson B M, Ross A H, Street C A
Toxicol Lett. 1982 Dec;14(3-4):221-7. doi: 10.1016/0378-4274(82)90055-8.
Young Wistar rats were fed gum arabic (GA) at dietary concentrations of 0% (two control groups), 1, 2, 4, 8 and 20% for 13 weeks. The criteria studied were body weights, food and water consumption, urinalysis, liver and kidney weights, clinical chemistry, haematology, and histology. No untoward effects were observed at dose levels below those which caused dietary imbalance. At the top dose, female rats showed a small reduction in kidney weight, caecal enlargement, and changes in serum urea and total CO2. Male rats showed no differences from the control groups at dietary concentrations up to approx. 8%, but food and water consumption, body weight, liver and kidney weights all decreased significantly and caecal enlargement was evident at the top dose tested. There were no histological changes and no significant changes in haematological parameters in male or female rats at the top dose tested. The no-untoward effect concentrations were 8.6% (5.2 g/kg/day) and 18.1% (13.8 g/kg/day) for male and female rats respectively.
将年轻的Wistar大鼠分别喂食阿拉伯胶（GA），其在饮食中的浓度为0%（两个对照组）、1%、2%、4%、8%和20%，持续13周。所研究的标准包括体重、食物和水摄入量、尿液分析、肝脏和肾脏重量、临床化学、血液学和组织学。在低于导致饮食失衡的剂量水平下未观察到不良影响。在最高剂量时，雌性大鼠肾脏重量略有减轻、盲肠肿大，血清尿素和总二氧化碳水平发生变化。雄性大鼠在饮食浓度高达约8%时与对照组无差异，但在测试的最高剂量下，食物和水摄入量、体重、肝脏和肾脏重量均显著下降，盲肠肿大明显。在测试的最高剂量下，雄性或雌性大鼠均无组织学变化，血液学参数也无显著变化。雄性和雌性大鼠的无不良影响浓度分别为8.6%（5.2克/千克/天）和18.1%（13.8克/千克/天）。
