致癌物对大鼠肝增生性结节诱导的依途径、器官特异性效应。

Route-dependent, organ-specific effects of carcinogens on induction of hyperplastic liver nodules in rats.

作者信息

Hasegawa R, Tsuda H, Nakanishi K, Tatematsu M, Ito N

出版信息

Toxicol Lett. 1982 Dec;14(3-4):229-35. doi: 10.1016/0378-4274(82)90056-x.

Abstract

The inductions of hyperplastic liver nodules (HN) by four carcinogens were examined by their administration continuously and repeatedly by intragastric (i.g.), intraperitoneal (i.p.), intravenous (i.v.) and/or subcutaneous (s.c.) injections before (initiation stage) or after (promotion stage) exposure to N-2-fluorenylacetamide (2-FAA) in male F344 rats. Diethylnitrosamine (DEN), a water-soluble hepatocarcinogen, and 3'-methyl-4-dimethylaminobenzene (3'-Me-DAB), a water-insoluble hepatocarcinogen, markedly increased development of HN when administered by any route in both stages. However, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a water-soluble non-hepatocarcinogen, and benzo[a]pyrene (B[a]P), a water-insoluble non-hepatocarcinogen, increased HN slightly by all or some of the routes of application only in the initiation stage. The influence of the administration route was more evident with water-insoluble compounds in the promotion stage and with non-hepatocarcinogens in the initiation stage.

摘要

通过在雄性F344大鼠接触N - 2 - 芴基乙酰胺（2 - FAA）之前（启动阶段）或之后（促进阶段），通过胃内（i.g.）、腹腔内（i.p.）、静脉内（i.v.）和/或皮下（s.c.）注射连续反复给予四种致癌物，研究了它们对增生性肝结节（HN）的诱导作用。水溶性肝癌致癌物二乙基亚硝胺（DEN）和水不溶性肝癌致癌物3'-甲基-4-二甲基氨基苯（3'-Me - DAB），在两个阶段通过任何途径给药时，均显著增加了HN的发生。然而，水溶性非肝癌致癌物N - 甲基 - N'-硝基 - N - 亚硝基胍（MNNG）和水不溶性非肝癌致癌物苯并[a]芘（B[a]P），仅在启动阶段通过全部或部分应用途径使HN略有增加。给药途径的影响在促进阶段对水不溶性化合物以及在启动阶段对非肝癌致癌物更为明显。