Wolf M, Angerstein W
Z Erkr Atmungsorgane. 1982;159(2):215-20.
Ultrasonic Nebulizers show a variation of aerosol density during the breathing cycle that affects deposition. First there is a relatively dense fraction of aerosol that penetrates deeply into the lung, while the subsequently delivered aerosol reaches only the upper parts of the airways. Calculations show that the effect has a pronounced influence on deposition. The percentage of medicament deposited in the lower airways is significantly increased, although the total amount of medicament is lower than with an aerosol of uniform density.
超声雾化器在呼吸周期中会出现气溶胶密度变化，这会影响药物沉积。首先，有一部分相对密集的气溶胶会深入肺部，而随后输送的气溶胶只能到达气道上部。计算表明，这种效应会对沉积产生显著影响。尽管药物总量低于密度均匀的气溶胶，但在下呼吸道沉积的药物百分比会显著增加。
