Newman S P, Pavia D, Garland N, Clarke S W
Eur J Respir Dis Suppl. 1982;119:57-65.
The deposition of aerosol consisting of Teflon particles (mass median aerodynamic diameter 3.2 micrometers) labelled with 99Tcm has been measured in patients with obstructive airways disease. Aerosol was inhaled at 30 l min-1 with 4 s breath holding (patient group A) and at 30 l min-1 with 10 s breath holding (patient group B). A further group of patients (group C) inhaled at 90 l min-1 with 10 s breath holding. Each subject was given the aerosol during inhalation at three different lung volumes (20% VC, 50% VC and 80% VC) on three different days. The greatest whole lung, tracheobronchial and alveolar depositions occurred in group B patients, irrespective of the lung volume of aerosol actuation. By comparison, deposition was similar in groups A and C only when the aerosol was actuated at 20% VC. Whole lung deposition in groups A and B was significantly correlated both with the bronchodilator response to terbutaline sulphate aerosol administered under the same inhalation conditions and with the residence time of airborne particles in the respiratory tract. The optimum inhalation technique for a beta-adrenergic aerosol indicated by these data (slow inhalation with 10 s breath holding) confirms the results of previous studies.
已对患有阻塞性气道疾病的患者进行了测量，测量内容为含有用99锝标记的聚四氟乙烯颗粒（质量中值空气动力学直径为3.2微米）的气雾剂的沉积情况。气雾剂以30升/分钟的流速吸入，屏气4秒（A组患者）以及以30升/分钟的流速吸入，屏气10秒（B组患者）。另一组患者（C组）以90升/分钟的流速吸入，屏气10秒。在三天内，让每位受试者在三种不同肺容量（肺活量的20%、50%和80%）下吸入气雾剂。无论气雾剂启动时的肺容量如何，B组患者的全肺、气管支气管和肺泡沉积量最大。相比之下，仅当气雾剂在肺活量的20%时启动时，A组和C组的沉积情况相似。A组和B组的全肺沉积与在相同吸入条件下给予硫酸特布他林气雾剂后的支气管扩张反应以及空气中颗粒在呼吸道中的停留时间均显著相关。这些数据表明的β-肾上腺素能气雾剂的最佳吸入技术（缓慢吸入并屏气10秒）证实了先前研究的结果。
