Stahlhofen W, Gebhart J, Heyder J, Scheuch G
Bull Eur Physiopathol Respir. 1983 Sep-Oct;19(5):459-63.
Total and regional deposition data for aerosol particles in the human respiratory tract measured in normal mouth-breathing subjects are applied to aerosols from medical nebulizers. From deposition data as a function of particle size and respiratory parameters and from the droplet size distributions of various jet and ultrasonic nebulizers, integral mass depositions as a fraction of the aerosol entering the mouthpiece are determined for the total respiratory tract, the extrathoracic airways, the tracheobronchial tree and the alveolar region. Since the aim of inhalation therapy is the deposition of particles in that part of the respiratory tract which is to be treated, the results of this study may also be useful in finding out optimum conditions in cases of therapeutic applications.
在正常口呼吸受试者中测量得到的人体呼吸道中气溶胶颗粒的总沉积和区域沉积数据被应用于医用雾化器产生的气溶胶。根据作为粒径和呼吸参数函数的沉积数据以及各种喷射式和超声雾化器的液滴尺寸分布，确定了进入吸嘴的气溶胶中作为分数的总呼吸道、胸外气道、气管支气管树和肺泡区域的积分质量沉积。由于吸入疗法的目的是使颗粒沉积在要治疗的呼吸道部分，本研究结果在找出治疗应用情况下的最佳条件时可能也有用。
