Yamamoto M, Enzan H, Hara H, Iijima S
Acta Pathol Jpn. 1978 Jul;28(4):513-21. doi: 10.1111/j.1440-1827.1978.tb00891.x.
Findings of perivascular mesenchymal cells and fibroblasts in mice receiving large doses of vitamin A were described. Liver, lung, intestine and skin were investigated by fluorescence and electron microscopy. Marked increase of fluorescence of vitamin A was observed in the sinusoidal wall of the liver, in the alveolar septa of the lungs, in the propria mucosa, submucosa and muscular layer of the intestine and in the dermis of the abdominal skin. Increased fluorescence of these organs corresponded, ultrastructually, to the appearance of numerous fat droplets in Ito cells of the liver, septal cells of the lung and fibroblasts of the intestine and of the skin. All of these cells showed the same morphological features and the same distribution in the tissue, namely in the interstitial connective tissue space. These findings indicate that vitamin A storing cells are distributed widely in the connective tissue of various organs and that perivascular vitamin A storing mesenchymal cells and interstitial fibroblasts are probably of common fibroblastic cell line.
描述了接受大剂量维生素A的小鼠血管周围间充质细胞和成纤维细胞的发现。通过荧光显微镜和电子显微镜对肝脏、肺、肠道和皮肤进行了研究。在肝脏的窦壁、肺的肺泡间隔、肠道的固有黏膜、黏膜下层和肌层以及腹部皮肤的真皮中观察到维生素A荧光明显增加。这些器官荧光的增加，在超微结构上，对应于肝脏的贮脂细胞、肺的间隔细胞以及肠道和皮肤的成纤维细胞中出现大量脂滴。所有这些细胞在组织中表现出相同的形态特征和相同的分布，即在间质结缔组织间隙。这些发现表明，维生素A储存细胞广泛分布于各种器官的结缔组织中，血管周围储存维生素A的间充质细胞和间质成纤维细胞可能来自共同的成纤维细胞系。
