Spit B J
Exp Lung Res. 1983 May;4(4):247-57. doi: 10.3109/01902148309055012.
To investigate the effect of vitamin A on the occurrence of lipid droplets in alveolar fibroblasts, light and electron microscopic studies were carried out on the lungs of Syrian golden hamsters fed on diets with a low, normal, or high vitamin A content for a period of 17 weeks. The feeding of the high vitamin A diet resulted in a considerable increase in size and number of lipid droplets in alveolar fibroblasts. These droplets also occurred in fibroblasts of the visceral pleura, and in fibroblasts of connective tissue around bronchioli and larger blood vessels. Most of the lipid-laden fibroblasts could be recognized as myofibroblasts. The significance of the droplets for the deposition of interstitial materials or for the synthesis of prostaglandins is discussed.
为研究维生素A对肺泡成纤维细胞中脂滴形成的影响，对喂食低、正常或高维生素A含量饮食17周的叙利亚金黄地鼠的肺组织进行了光镜和电镜研究。高维生素A饮食喂养导致肺泡成纤维细胞中脂滴的大小和数量显著增加。这些脂滴也出现在脏层胸膜的成纤维细胞以及细支气管和较大血管周围结缔组织的成纤维细胞中。大多数含脂成纤维细胞可被识别为肌成纤维细胞。文中讨论了这些脂滴对于间质物质沉积或前列腺素合成的意义。
