Hamberg H, Brunk U, Ericsson J L, Jung B
Acta Pathol Microbiol Scand A. 1978 Nov;86A(6):487-94. doi: 10.1111/j.1699-0463.1978.tb02074.x.
Cultured, density-dependent growth inhibited human glia cells were exposed to X-radiation, generated by an 8-MeV linear accelerator, at a dose of 200 Gy. Phase contrast microscopy, time-lapse cinemicrography and scanning electron microscopy showed the irradiated cells to have increased ruffling activity of plasma membranes and enhanced macropinocytosis with a maximum approximately 24 hours after irradiation. "Atypical" central ruffles arising from the upper cell surface were demonstrated on some irradiated cells. The turnover of plasma membranes was supposed to be increased in the irradiated cells resulting in the formation of the observed branched, thread-like cells. The diminished cell surface area was believed to result from an unbalance between degradation and renewal of the plasma membranes in the irradiated cells.
将培养的、密度依赖性生长受抑制的人类神经胶质细胞暴露于由一台8兆电子伏特直线加速器产生的剂量为200戈瑞的X射线下。相差显微镜检查、延时电影显微镜检查和扫描电子显微镜检查显示，受照射细胞的质膜褶皱活性增加，巨胞饮作用增强，在照射后约24小时达到最大值。在一些受照射细胞上发现了从细胞上表面产生的“非典型”中央褶皱。据推测，受照射细胞的质膜周转率增加，导致形成观察到的分支状、丝状细胞。细胞表面积减小被认为是由于受照射细胞的质膜降解和更新之间失衡所致。
