[14C]标记的黄曲霉毒素B1在小鼠体内的分布
Distribution of [14C]-labelled aflatoxin B1 in mice.
作者信息
Arora R G, Appelgren L E, Bergman A
出版信息
Acta Pharmacol Toxicol (Copenh). 1978 Oct;43(4):273-9. doi: 10.1111/j.1600-0773.1978.tb02265.x.
Abstract
The distribution of [14C]-labelled aflatoxin B1 has been studied in mice with the aid of whole-body autoradiography. In addition to the localisation of labelled aflatoxin B1 and/or its metabolities in the liver, bile, kidney, lung and urine an uptake of 14C in the pigment of the Harderian gland and the eye was observed. Uptake of radioactivity was also found in the eyes of the foetuses although their livers did not accumulate radioactivity.
摘要
借助全身放射自显影技术，对小鼠体内[14C]标记的黄曲霉毒素B1的分布进行了研究。除了标记的黄曲霉毒素B1和/或其代谢产物在肝脏、胆汁、肾脏、肺和尿液中的定位外，还观察到哈德氏腺和眼睛色素中摄取了14C。尽管胎儿的肝脏没有积累放射性，但在胎儿的眼睛中也发现了放射性摄取。
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