Lindström C G, Rosengren J E, Ekberg O
Acta Radiol Diagn (Stockh). 1978;19(5):799-816. doi: 10.1177/028418517801900510.
In 189 rats N-methyl-N'-nitro-N-nitrosoguanidine or 1,2-dimethylhydrazine (DMH) was given in order to induce colonic tumours. The tumour induction was followed by double contrast examination. At 894 examinations 196 adenomatous tumours were revealed. Autopsy and microscopy revealed 214 macroscopic and 53 microscopic benign or malignant adenomatous tumours. Metastases were found in 17 per cent in the DMH group. The relationship between adenomas and carcinomas is also evaluated.
为诱导结肠肿瘤，对189只大鼠给予N-甲基-N'-硝基-N-亚硝基胍或1,2-二甲基肼（DMH）。诱导肿瘤后进行双重对比检查。在894次检查中发现了196个腺瘤性肿瘤。尸检和显微镜检查发现了214个宏观和53个微观良性或恶性腺瘤性肿瘤。在DMH组中发现转移的比例为17%。还评估了腺瘤与癌之间的关系。
