Paksy K A, Moinár J, Náray M, Barcza G
Acta Physiol Acad Sci Hung. 1982;59(4):317-24.
Solvents were tested for their influence on motivational state, as well as for their sedative effects, after intraperitoneal administration. The following tests were used: open field (exploratory activity, locomotion), activity wheel (running activity), tube test and tilted plane (muscle weakness, incoordination). The agents proved to be similar in causing muscle weakness and ataxia already at low dose levels. Benzene was the most potent in this respect. The three solvents, however, contrasted strongly in influencing motor activity. While benzene and especially toluene exerted CNS stimulation, no such effect could be detected following m-xylene treatment. On the basis of human experiences with these substances it may be suggested that the screening procedure applied in rats might be useful for predicting acute adverse effects in man.
在腹腔注射后，测试了溶剂对动机状态的影响以及它们的镇静作用。使用了以下测试：旷场试验（探索性活动、运动）、活动轮试验（跑步活动）、管试验和倾斜平面试验（肌肉无力、不协调）。这些药剂在低剂量水平时就已被证明在导致肌肉无力和共济失调方面相似。在这方面，苯的作用最强。然而，这三种溶剂在影响运动活动方面有很大差异。虽然苯尤其是甲苯会产生中枢神经系统刺激作用，但间二甲苯处理后未检测到这种效果。根据人类对这些物质的经验，可以认为在大鼠中应用的筛选程序可能有助于预测对人类的急性不良反应。
