Marklund S L, Holme E, Hellner L
Clin Chim Acta. 1982 Nov 24;126(1):41-51. doi: 10.1016/0009-8981(82)90360-6.
Serum from healthy volunteers contained very little CuZn superoxide dismutase. Larger amounts were found in serum from patients with impaired renal function, and there was a good correlation between serum creatinine and serum CuZn superoxide dismutase content. Almost all superoxide dismutase activity of human serum was cyanide sensitive, and was found to be given by a factor(s) with a molecular mass of approximately 130000. The factor was found in all human extracellular fluids investigated: plasma, serum, lymph, ascites and cerebrospinal fluid. The factor was not recognized by radioimmunoassay for human CuZn superoxide dismutase, and it was not inhibited by rabbit antibodies against human CuZn superoxide dismutase. A similar high-molecular mass factor was found in plasma from all mammals investigated: horse, cow, pig, dog, cat, rabbit, rat and mouse. The activities differed much among species and were mostly higher than those found in human serum/plasma.
健康志愿者的血清中铜锌超氧化物歧化酶含量极少。肾功能受损患者的血清中该酶含量较高，且血清肌酐与血清铜锌超氧化物歧化酶含量之间存在良好的相关性。人血清中几乎所有的超氧化物歧化酶活性对氰化物敏感，且发现其由一种分子量约为130000的因子产生。在所研究的所有人细胞外液中均发现了该因子：血浆、血清、淋巴液、腹水和脑脊液。放射免疫分析法未识别出该因子与人铜锌超氧化物歧化酶相同，且兔抗人铜锌超氧化物歧化酶抗体也不能抑制其活性。在所有所研究的哺乳动物的血浆中均发现了类似的高分子量因子：马、牛、猪、狗、猫、兔、大鼠和小鼠。不同物种之间的活性差异很大，且大多高于人血清/血浆中的活性。
