Lake A M, Stauffer J Q, Stuart M J
Am J Dig Dis. 1978 Oct;23(10):897-902. doi: 10.1007/BF01072463.
Twelve patients with acute, untreated inflammatory bowel disease (IBD) were followed prospectively for coagulation and platelet function. With no symptomatic coagulopathy, abnormalities were found in all patients. With acute diseases, elevations of fibrinogen (9/12), factor V (8/12), and factor VIII (6/12) were common. Depressions of antithrombin III levels were also observed acutely (8/12). Abnormalities of platelets were both quantitative and qualitative. Thrombocytosis was present (11/12), and abnormalities in the rate and percent platelet aggregation were seen (9/10). During therapy, factors V and VIII, antithrombin III levels, and the quantitative and qualitative platelet abnormalities returned towards normal in direct correlation with sedimentation rate and clinical disease activity.
对12例未经治疗的急性炎症性肠病（IBD）患者的凝血和血小板功能进行了前瞻性随访。在没有症状性凝血病的情况下，所有患者均发现异常。在急性疾病中，纤维蛋白原升高（9/12）、因子V升高（8/12）和因子VIII升高（6/12）很常见。抗凝血酶III水平也在急性期出现降低（8/12）。血小板异常包括数量和质量方面。存在血小板增多（11/12），并且观察到血小板聚集率和百分比异常（9/10）。在治疗期间，因子V和VIII、抗凝血酶III水平以及血小板数量和质量异常与血沉率和临床疾病活动度直接相关，恢复至正常水平。
