Miura S, Asakura H, Morishita T, Kobayashi K, Yoshioka M, Morita A, Tsuchiya M
Digestion. 1982;25(2):103-14. doi: 10.1159/000198818.
This study was performed to clarify how disturbance of lipid metabolism occurred in patients with protein-losing enteropathy (PLE) as compared with that of control individuals and patients with malabsorption syndrome. Analysis of plasma lipids at fasting state showed a decreased proportion of essential fatty acid, especially linoleic and arachidonic acid fractions in patients with malabsorption syndrome as well as in patients with PLE group A, which was due to proven disorders of intestinal lymphatics. An increase in percentage of oleic acid fraction and a percentage increase in plasma triglyceride levels after an oral administration of olive oil was depressed in patients with malabsorption syndrome and PLE group A when compared with that of normal subjects. Patients with PLE group B, which was not due to major lymphatic disorders, were similar to normal in these parameters. These abnormalities were found to be marked when remarkable abnormalities of lymphatics were accompanied.
本研究旨在阐明与对照个体及吸收不良综合征患者相比，蛋白质丢失性肠病（PLE）患者的脂质代谢紊乱是如何发生的。空腹状态下血浆脂质分析显示，吸收不良综合征患者以及PLE A组患者中必需脂肪酸的比例降低，尤其是亚油酸和花生四烯酸部分，这是由于已证实的肠道淋巴管疾病所致。与正常受试者相比，吸收不良综合征患者和PLE A组患者口服橄榄油后油酸部分百分比增加及血浆甘油三酯水平百分比增加受到抑制。非主要淋巴管疾病所致的PLE B组患者在这些参数方面与正常患者相似。当伴有明显的淋巴管异常时，这些异常表现更为显著。
