Nadeau J H, Collins R L, Klein J
Genetics. 1982 Nov;102(3):583-98. doi: 10.1093/genetics/102.3.583.
To test the hypothesis that the H-2 polymorphism is adaptive, the degree of polymorphism of loci linked to the H-2 complex on chromosome 17 of the house mouse was compared to the degree of polymorphism of loci located on other chromosomes. Published theoretical analyses show that polymorphisms subject to natural selection usually reduce the polymorphism of linked neutral loci. The first test of the hypothesis was based on data obtained from a survey of the polymorphism of 12 isozyme-encoding loci in wild house mice from Europe, North Africa and South America. Results of this test showed that, on the average, H-2 linked loci were as polymorphic as loci located on other chromosomes. In fact, the data suggested that H-2 linked loci might be more polymorphic than other loci. To test this hypothesis more rigorously, data for the 12 isozyme-encoding loci were augmented with data from published surveys of the polymorphisms of 59 loci in house mice from Europe and North America. Results of these tests showed that polymorphic loci linked to the H-2 complex tended to be more, rather than less, polymorphic than loci located on other chromosomes. The cluster of highly polymorphic loci seems to be related to linkage of these loci to the highly polymorphic H-2 complex, but the way in which the influence is exerted could not be readily explained.
为了检验H-2多态性具有适应性这一假说，将家鼠17号染色体上与H-2复合体连锁的基因座的多态性程度，与位于其他染色体上的基因座的多态性程度进行了比较。已发表的理论分析表明，受自然选择影响的多态性通常会降低连锁中性基因座的多态性。该假说的首次检验基于对来自欧洲、北非和南美洲的野生家鼠中12个同工酶编码基因座的多态性调查所获得的数据。这项检验的结果表明，平均而言，与H-2连锁的基因座和位于其他染色体上的基因座一样具有多态性。事实上，数据表明与H-2连锁的基因座可能比其他基因座具有更高的多态性。为了更严格地检验这一假说，将12个同工酶编码基因座的数据与来自已发表的对欧洲和北美洲家鼠中59个基因座的多态性调查的数据相结合。这些检验的结果表明，与H-2复合体连锁的多态性基因座往往比位于其他染色体上的基因座具有更多而非更少的多态性。高度多态性基因座的簇似乎与这些基因座与高度多态性的H-2复合体的连锁有关，但这种影响的施加方式却难以解释。
