Gal-Or L, Gonen R, Zilberman A, Scharf M
J Biomed Mater Res. 1982 Nov;16(6):785-98. doi: 10.1002/jbm.820160605.
It has been shown previously that supplementing plastic intrauterine devices (IUDs) with copper wire enhances the antifertility effect of the device. The use of copper intrauterine contraceptive devices, however, is currently limited to two to three years, mainly because of wire fragmentation, which was observed as early as after eight months of use. In the resulting search for a long-lasting device, two new systems of duplex wire, with gold and platinum cores electrolytically coated with copper, were devised and studied. Initially, duplex wires and controls were exposed to physiological solution. Copper dissolution rate and corrosion morphology were studied by weight-loss measurements and optical metallography. Similar systems were then surgically implanted in rat uteri for varying periods of up to 26 weeks. Electron microanalysis of corrosion products, in addition to weight-loss measurements and metallography, was performed. The results showed that a uniform and ductile copper coating is obtainable by electroplating on gold and platinum wires. Rate of copper dissolution is similar to that of solid copper wire. No dissolution of gold and platinum in the controls or coated wires was detected by weight loss, metallography, or atomic absorption measurements. Microanalysis of the deposits and corrosion products on the wires in the uteri environment showed sulfur, chlorine, and calcium, in addition to copper. The results of this study suggest that supplementing IUDs with copper-coated gold or platinum wires may result in significant prolongation of the life span of the device by preventing uncontrolled loss of copper caused by wire fragmentation.
先前的研究表明，在塑料宫内节育器（IUD）上添加铜丝可增强其抗生育效果。然而，目前铜宫内节育器的使用期限限制在两到三年，主要原因是早在使用八个月后就观察到了铜丝断裂。在寻求长效节育器的过程中，设计并研究了两种新型双股线系统，其金芯和铂芯通过电解法镀铜。最初，将双股线和对照物置于生理溶液中。通过失重测量和光学金相学研究铜的溶解速率和腐蚀形态。然后将类似的系统手术植入大鼠子宫长达26周的不同时间段。除了失重测量和金相学外，还对腐蚀产物进行了电子微分析。结果表明，通过在金线和铂线上电镀可获得均匀且有延展性的铜涂层。铜的溶解速率与实心铜丝相似。通过失重、金相学或原子吸收测量未检测到对照物或镀覆线中的金和铂溶解。对子宫环境中金属丝上的沉积物和腐蚀产物进行的微分析表明，除了铜之外还有硫、氯和钙。这项研究的结果表明，用镀铜的金线或铂线补充宫内节育器可能会通过防止因铜丝断裂导致的铜的无节制损失而显著延长节育器的使用寿命。
