MacIver A G, Thomas S M
J Trop Med Hyg. 1982 Oct;85(5):209-12.
Eight cases of multi-system amyloid have been found in 4235 autopsies (0.2%) performed at University College Hospital, Ibadan, Nigeria between 1970 and 1979. Blocks and sections of seven cases showed the organ distribution associated with secondary amyloid, involving kidney, spleen and liver. Potassium permanganate oxidation prior to Congo Red staining showed that all seven cases contained protein AA amyloid. Five patients had tuberculosis but in two patients there was no recognized cause, idiopathic AA amyloid. Patients usually presented with nephrotic syndrome or renal failure and hypertension was absent. There appears to be a low incidence of amyloidosis in Africans, despite the occurrence of a large number of potential amyloidogenic stimuli, indicating the importance of individual host reactivity and failure of amyloid degradation in the causation of amyloidosis.
1970年至1979年间，在尼日利亚伊巴丹大学学院医院进行的4235例尸检中发现了8例多系统淀粉样变（占0.2%）。7例的组织块和切片显示出与继发性淀粉样变相关的器官分布，累及肾脏、脾脏和肝脏。刚果红染色前的高锰酸钾氧化显示，所有7例均含有AA蛋白淀粉样物。5例患者患有结核病，但2例患者病因不明，为特发性AA淀粉样变。患者通常表现为肾病综合征或肾衰竭，无高血压。尽管存在大量潜在的淀粉样变诱发刺激因素，但非洲人淀粉样变的发病率似乎较低，这表明个体宿主反应性以及淀粉样物降解功能障碍在淀粉样变病因学中具有重要作用。
