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J Virol. 1982 Dec;44(3):1072-5. doi: 10.1128/JVI.44.3.1072-1075.1982.
2
Adenovirus-induced alterations of the cell growth cycle: a requirement for expression of E1A but not of E1B.腺病毒诱导的细胞生长周期改变：E1A表达的必要性而非E1B表达的必要性。
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Human adenovirus type 5 variants with sequence alterations flanking the E2A gene: effects on E2 expression and DNA replication.E2A基因侧翼存在序列改变的5型人腺病毒变体：对E2表达和DNA复制的影响
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Proc Natl Acad Sci U S A. 1986 Apr;83(7):2167-71. doi: 10.1073/pnas.83.7.2167.

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1
Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells.基因组 DNA 损伤和 ATR-Chk1 信号通路决定了溶瘤腺病毒在人卵巢癌细胞中的疗效。
J Clin Invest. 2011 Apr;121(4):1283-97. doi: 10.1172/JCI43976. Epub 2011 Mar 7.
2
Adenovirus-induced alterations of the cell growth cycle: a requirement for expression of E1A but not of E1B.腺病毒诱导的细胞生长周期改变：E1A表达的必要性而非E1B表达的必要性。
J Virol. 1983 Jan;45(1):192-9. doi: 10.1128/JVI.45.1.192-199.1983.
3
Control functions of adenovirus transformation region E1A gene products in rat and human cells.腺病毒转化区E1A基因产物在大鼠和人类细胞中的调控功能。
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Adenovirus E1A 12S protein induces DNA synthesis and proliferation in primary epithelial cells in both the presence and absence of serum.腺病毒E1A 12S蛋白在有血清和无血清的情况下均可诱导原代上皮细胞中的DNA合成和增殖。
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The release of growth arrest by microinjection of adenovirus E1A DNA.通过显微注射腺病毒E1A DNA实现生长停滞的解除。
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6
The amino-terminal region of the adenovirus serotype 5 E1a protein performs two separate functions when expressed in primary baby rat kidney cells.当在新生大鼠肾原代细胞中表达时，腺病毒5型E1a蛋白的氨基末端区域发挥两种不同的功能。
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7
Functions of the two adenovirus early E1A proteins and their conserved domains in cell cycle alteration, actin reorganization, and gene activation in rat cells.两种腺病毒早期E1A蛋白的功能及其保守结构域在大鼠细胞周期改变、肌动蛋白重组和基因激活中的作用。
J Virol. 1989 Jan;63(1):303-10. doi: 10.1128/JVI.63.1.303-310.1989.

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Identification of adenovirus 2 early genes required for induction of cellular DNA synthesis in resting hamster cells.鉴定在静止仓鼠细胞中诱导细胞DNA合成所需的腺病毒2型早期基因。
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A biochemical investigation of the adenovirus-induced G1 to S phase progression: thymidine kinase, ornithine decarboxylase, and inhibitors of polyamine biosynthesis.腺病毒诱导的G1期至S期进程的生化研究：胸苷激酶、鸟氨酸脱羧酶及多胺生物合成抑制剂
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Cell. 1981 Nov;26(3 Pt 1):371-9. doi: 10.1016/0092-8674(81)90206-3.
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Altered cell cycle progression and aberrant mitosis in adenovirus-infected rodent cells.腺病毒感染的啮齿动物细胞中细胞周期进程改变及有丝分裂异常。
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腺病毒诱导的细胞生长周期改变：早期区域E2A和E2B突变的影响

Adenovirus-induced alterations of the cell growth cycle: effects of mutations in early regions E2A and E2B.

作者信息

Murray J D, Braithwaite A W, Taylor I W, Bellett A J

出版信息

J Virol. 1982 Dec;44(3):1072-5. doi: 10.1128/JVI.44.3.1072-1075.1982.

DOI:10.1128/JVI.44.3.1072-1075.1982
PMID:7176017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC256368/
Abstract

Mutants ts125 (E2A) and ts36 (E2B) of adenovirus type 5 induced alterations to cell cycle progression at the nonpermissive temperature which were detectable by flow cytometry. Thus neither E2A, nor gene N in E2B, is required for these effects. Whereas the wild-type virus induced cells with aneuploid (between 4n and 8n) DNA contents, as did ts125 at the permissive temperature, ts125 induced peaks of cells with 8n, 16n, and 32n DNA contents at the nonpermissive temperature. This was probably due to the failure of regulation of E1A by E2.

摘要

5型腺病毒的突变体ts125（E2A）和ts36（E2B）在非允许温度下诱导细胞周期进程发生改变，这种改变可通过流式细胞术检测到。因此，这些效应既不需要E2A，也不需要E2B中的基因N。野生型病毒诱导细胞具有非整倍体（4n至8n之间）的DNA含量，ts125在允许温度下也是如此，但ts125在非允许温度下诱导出DNA含量为8n、16n和32n的细胞峰。这可能是由于E2对E1A的调节失败所致。