Hebb J H, Caplan Y H, Crooks C R, Mergner W J
J Anal Toxicol. 1982 Sep-Oct;6(5):209-16. doi: 10.1093/jat/6.5.209.
Blood, urine, heart, liver, and psoas muscle concentrations of tricyclic antidepressant (TCA) drugs and their N-desmethyl metabolites were determined in forty medical examiner cases. The cases were evaluated for the role played by the TCA drugs in the cause of death and compared to a literature survey of previously reported cases. The incidence of the various individual TCA drugs as a factor and the significance of the disposition of the drugs and their metabolites is included. Comparing TCA drug concentrations in the heart and skeletal muscle and considering the differences in perfusion to these organs, TCA drugs and metabolites showed an affinity for the cardiac over the skeletal muscle. The case results were correlated with experimental studies to suggest the relationships of blood concentrations with toxicity.
在40例法医尸检案例中测定了三环类抗抑郁药（TCA）及其N-去甲基代谢产物在血液、尿液、心脏、肝脏和腰大肌中的浓度。对这些案例评估了TCA药物在死因中所起的作用，并与先前报道案例的文献调查进行了比较。其中包括各种TCA药物作为一个因素的发生率以及药物及其代谢产物处置的意义。比较心脏和骨骼肌中的TCA药物浓度，并考虑到这些器官灌注的差异，TCA药物及其代谢产物对心脏的亲和力高于骨骼肌。将案例结果与实验研究相关联，以提示血药浓度与毒性之间的关系。
