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RAST技术在黄蜂蜇伤超敏反应中的应用。特别考虑了各种昆虫抗原之间的交叉反应。

Use of RAST technique in wasp sting hypersensitivity. Cross-reactions between various insect antigens are specially considered.

作者信息

Müller U, Roth A, Yman L, Patrizzi R

出版信息

Allergy. 1978 Aug;33(4):197-202. doi: 10.1111/j.1398-9995.1978.tb01534.x.

DOI:10.1111/j.1398-9995.1978.tb01534.x
PMID:717704
Abstract

Clinical hypersensitivity to wasp stings was found to be fairly well correlated with the presence of serum IgE-antibodies against yellow jacket venom as detected by the RAST technique. Such antibodies were never found in a control group of non-allergic blood donors, but they were detected in a surprisingly large proportion of patients with bee sting allergy without known allergic reactions to wasps. Studies using RAST inhibition technique failed to prove cross-reactions between bee and wasp venoms. Considerably better results were obtained when venom antigens instead of whole body antigens were used in the RAST. RAST inhibition studies suggested that IgE-antibodies detected with RAST using whole body antigen are directed against bee venom constituents in the whole body extract.

摘要

通过放射变应原吸附试验(RAST)技术检测发现,黄蜂蜇伤的临床超敏反应与血清中针对黄夹克毒液的IgE抗体的存在有相当好的相关性。在非过敏献血者的对照组中从未发现此类抗体,但在相当大比例的对蜜蜂蜇伤过敏但对黄蜂无已知过敏反应的患者中检测到了此类抗体。使用RAST抑制技术的研究未能证明蜜蜂和黄蜂毒液之间存在交叉反应。当在RAST中使用毒液抗原而非全身体抗原来代替时,获得了相当好得多的结果。RAST抑制研究表明,使用全身体抗原通过RAST检测到的IgE抗体是针对全身体提取物中的蜜蜂毒液成分的。

相似文献

1
Use of RAST technique in wasp sting hypersensitivity. Cross-reactions between various insect antigens are specially considered.RAST技术在黄蜂蜇伤超敏反应中的应用。特别考虑了各种昆虫抗原之间的交叉反应。
Allergy. 1978 Aug;33(4):197-202. doi: 10.1111/j.1398-9995.1978.tb01534.x.
2
[Significance of skin test and RAST in the diagnosis of insect sting allergy (author's transl)].皮肤试验和放射变应原吸附试验在昆虫叮咬过敏诊断中的意义(作者译)
Wien Med Wochenschr. 1981;131(11):301-3.
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Comparison of skin tests and RAST for the diagnosis of bee sting allergy.皮肤试验与放射性变应原吸附试验在蜂蜇过敏诊断中的比较。
Allergy. 1979 Aug;34(4):249-56. doi: 10.1111/j.1398-9995.1979.tb01705.x.
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Stinging insect allergy: detection and clinical significance of venom IgE antibodies.螫刺昆虫过敏:毒液IgE抗体的检测及临床意义
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Diagnosis of Polistes wasp hypersensitivity.胡蜂过敏的诊断。
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Insect sting allergy with negative venom skin test responses.毒液皮肤试验反应阴性的昆虫叮咬过敏
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Serological investigations in hymenoptera sting allergy: IgE and haemagglutinating antibodies against bee venom in patients with bee sting allergy, bee keepers and non-allergic blood donors.
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Insect allergy. A comparative study including case histories and immunological parameters.昆虫过敏。一项包括病例史和免疫学参数的对比研究。
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The frequency and clinical significance of specific IgE to both wasp (Vespula) and honey-bee (Apis) venoms in the same patient.同一患者体内对黄蜂(胡蜂属)和蜜蜂(蜜蜂属)毒液的特异性IgE的频率及临床意义。
Clin Exp Allergy. 1998 Jan;28(1):26-34. doi: 10.1046/j.1365-2222.1998.00176.x.

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