Shaternikov V A, Kuvaeva I D, Ladodo K S, Orlova N G, Veselova O L
Vopr Pitan. 1982 Sep-Oct(5):51-6.
The authors describe the results of studies into the common and local humoral immunological system in 60 children under one year of age suffering from atopic dermatitis of varying severity. The passive hemagglutination test with the use of a kit of erythrocytic diagnosticums devised at the Institute of Nutrition, Academy of Medical Sciences of the USSR, was used to study the degree of the child's body sensitization with cow's milk antigens and the content of IgG, IgM and IgA in the blood and that of secretory IgA in coprofiltrates. Polyvalent sensitization of the body with food antigens was found in 50% of the children examined to reveal an interplay between the degree of sensitization with the severity of the pathological process. It was demonstrated that penetration of food antigens through the epithelial barrier of the gastrointestinal tract was not related to the deficiency of the secretory IgA, since this class of immune proteins was detectable in the coprofiltrates from all the children. Besides, the content of these proteins was not reduced during the severe form of the disease. In this case, the intestine of all the children examined showed dysbacteriosis which needed correction. The blood serum manifested a decrease in the level of IgM and IgG which was more pronounced in the patients with a severe disease course.
作者描述了对60名1岁以下患有不同严重程度特应性皮炎的儿童的常见和局部体液免疫系统的研究结果。使用苏联医学科学院营养研究所研制的一套红细胞诊断试剂盒进行被动血凝试验，以研究儿童机体对牛奶抗原的致敏程度以及血液中IgG、IgM和IgA的含量，以及粪便滤液中分泌型IgA的含量。在50%的受检儿童中发现机体对食物抗原有多价致敏现象，这揭示了致敏程度与病理过程严重程度之间的相互作用。结果表明，食物抗原透过胃肠道上皮屏障与分泌型IgA缺乏无关，因为在所有儿童的粪便滤液中均可检测到这类免疫蛋白。此外，在疾病的严重阶段，这些蛋白的含量并未降低。在这种情况下，所有受检儿童的肠道均显示出需要纠正的菌群失调。血清中IgM和IgG水平降低，在病程严重的患者中更为明显。
