Kazarian G M
Antibiotiki. 1978 Nov;23(11):993-7.
When tetracycline was used for a long period of time, constant changes in the distribution regularities of free and bound fractions of the drug were observed. The changes were accompanied by a successive increase in the concentrations of both the fractions in the animal organs, tissues and fluids, as well as by a change in their levels, accumulation rate and percentage content.
长期使用四环素时，可观察到药物游离部分和结合部分的分布规律不断变化。这些变化伴随着动物器官、组织和体液中这两种组分浓度的持续增加，以及它们的水平、蓄积率和百分比含量的变化。
