Rudenko T G, Sychenikov I A, Nikolaev A V
Antibiotiki. 1978 Mar;23(3):250-3.
The quantitative indices and regularities of tetracycline hydrochloride binding with colelagen in the process of complex formation were studied in vitro. It was found that tetracycline-interacted with collagen. The amount of the antibiotic bound depended on its initial concentration in the mixture and the aggregate state of the protein: the amount of tetracycline hydrochloride absorbed by dissloved collagen was 10 times higher than that absorbed by polymerized collagen. The antibiotic bound with collagen did not lose its specific antibacterial activity.
在体外研究了盐酸四环素与胶原蛋白形成复合物过程中结合的定量指标和规律。发现四环素与胶原蛋白相互作用。结合的抗生素量取决于其在混合物中的初始浓度和蛋白质的聚集状态：溶解的胶原蛋白吸收的盐酸四环素量比聚合的胶原蛋白吸收的量高10倍。与胶原蛋白结合的抗生素并未丧失其特定的抗菌活性。
