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恶性萎缩性丘疹病:阿司匹林和双嘧达莫治疗

Malignant atrophic papulosis: treatment with aspirin and dipyridamole.

作者信息

Stahl D, Thomsen K, Hou-Jensen K

出版信息

Arch Dermatol. 1978 Nov;114(11):1687-9. doi: 10.1001/archderm.114.11.1687.

DOI:10.1001/archderm.114.11.1687
PMID:718220
Abstract

On electron microscopy of the endothelial cells of a patient with cutaneous and CNS symptoms of malignant atrophic papulosis, paramyxovirus-like particles could be seen in the cytoplasm. These particles were interpreted as degenerative changes that were due to ischemia. Coagulation studies showed increased thrombocyte aggregation, and treatment with the platelet-suppressive drugs, aspirin and dipyridamole, was instituted. This treatment resulted in a normal thrombocyte aggregation after eight months and complete clinical remission, which still persisted four months after cessation of therapy.

摘要

在对一名患有恶性萎缩性丘疹病皮肤和中枢神经系统症状患者的内皮细胞进行电子显微镜检查时,可在细胞质中看到副粘病毒样颗粒。这些颗粒被解释为由于缺血导致的退行性改变。凝血研究显示血小板聚集增加,于是开始使用血小板抑制药物阿司匹林和双嘧达莫进行治疗。该治疗在八个月后使血小板聚集恢复正常,并实现了完全临床缓解,在治疗停止四个月后仍持续缓解。

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Malignant atrophic papulosis: treatment with aspirin and dipyridamole.恶性萎缩性丘疹病:阿司匹林和双嘧达莫治疗
Arch Dermatol. 1978 Nov;114(11):1687-9. doi: 10.1001/archderm.114.11.1687.
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Degos' disease treated with platelet-suppressive drugs.使用血小板抑制药物治疗的迪戈斯病。
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Malignant atrophic papulosis in an infant.婴儿恶性萎缩性丘疹病。
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Are agents affecting platelet functions clinically useful?影响血小板功能的药物在临床上有用吗?
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A case of Degos disease in pregnancy.妊娠期德戈斯病1例。
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Degos' disease: a rare condition simulating rheumatic diseases.德戈斯病:一种罕见的类似风湿性疾病的病症。
Clin Rheumatol. 2009 Jul;28(7):861-3. doi: 10.1007/s10067-009-1164-5. Epub 2009 Mar 20.
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Degos' disease (malignant atrophic papulosis) as a fatal cause of acute abdomen: report of a case.迪戈斯病(恶性萎缩性丘疹病)作为急性腹痛的致死原因:一例报告。
Surg Today. 2008;38(9):866-70. doi: 10.1007/s00595-007-3728-9. Epub 2008 Aug 28.
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An atypical paediatric case of malignant atrophic papulosis (Köhlmeier-Degos disease).一例非典型小儿恶性萎缩性丘疹病(科尔迈尔-德戈斯病)。
Eur J Pediatr. 1990 Apr;149(7):457-8. doi: 10.1007/BF01959394.