Thorgeirsson A, Fregert S
Acta Derm Venereol. 1977;57(3):253-6.
The sensitizing capacity of epoxy resins of diglycidylether-Bisphenol A type was investigated using the "guinea pig maximization test". One isolated resin had a molecular weight (MW) of 340, which is the lowest among this type of epoxy resin. The other resins were mixtures with different MWs. Their distribution is not known, but only their average MW. The low molecular weight resin sensitized all of the animals and can be classified as an extreme allergen. The sensitizing capacity decreased in inverse proportion to the increase in the average MW of the resin mixtures. The cross-testing also indicated that the resin mixtures with higher average MW contained enough of the low MW resin (MW 340) to render this resin a sensitizer. Bisphenol A did not sensitize the animals at all but epichlorhydrin sensitized 60%. It is evident that in order to formulate hypoallergenic epoxy resins it will be necessary to achieve sensitization of animals with isolated resins of varying molecular weight.
采用“豚鼠最大化试验”研究了双缩水甘油醚-双酚A型环氧树脂的致敏能力。一种分离出的树脂分子量（MW）为340，是此类环氧树脂中最低的。其他树脂为不同分子量的混合物。它们的分布情况未知，仅知其平均分子量。低分子量树脂使所有动物致敏，可归类为极强变应原。致敏能力与树脂混合物平均分子量的增加成反比下降。交叉试验还表明，平均分子量较高的树脂混合物含有足够的低分子量树脂（MW 340），使该树脂成为致敏剂。双酚A根本不会使动物致敏，但环氧氯丙烷使60%的动物致敏。显然，为了配制低致敏性环氧树脂，有必要用不同分子量的分离树脂使动物致敏。
