关于鱿鱼轴突膜对顺序电压钳和电流钳的反应。
On the squid axon membrane's response to sequential voltage and current clamps.
作者信息
Moore J W, Stockbridge N, Schiff S J
出版信息
Biophys J. 1982 Dec;40(3):259-62. doi: 10.1016/S0006-3495(82)84482-2.
Starzak and Starzak (1978. IEEE Trans. Biomed. Eng. 25:201-204.) proposed that, in cyclic application of current and voltage-clamps, the fidelity of the match of the output current with the original stimulus could be used to measure the spatial uniformity of voltage in a membrane. However, they failed to find such a match in experiments on either squid axons or an electronic model of a membrane patch. Computer simulations of such experiments show that the failure to return the initial pattern may arise from shortcomings of the instruments or instability of membrane characteristics. Logical arguments show that such cyclic experiments are not able to provide information about spatial gradients of membrane voltage.
斯塔扎克和斯塔扎克（1978年。《IEEE生物医学工程汇刊》25卷：201 - 204页）提出，在电流钳和电压钳的循环应用中，输出电流与原始刺激的匹配保真度可用于测量膜中电压的空间均匀性。然而，他们在乌贼轴突或膜片的电子模型实验中未能找到这种匹配。此类实验的计算机模拟表明，未能恢复初始模式可能源于仪器的缺陷或膜特性的不稳定性。逻辑论证表明，此类循环实验无法提供有关膜电压空间梯度的信息。
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