Brown W S, Marsh J T, LaRue A
Bull Los Angeles Neurol Soc. 1982;47:91-107.
Event-related potentials (ERPs) were recorded from 25 elderly patients and 26 normal controls to determine whether ERPs can aid in the differential diagnosis of depression and dementia. Two ERP measures were used: (1) P300 latency, and (2) N1 amplitude increase for a 14db tone intensity increase (i.e. intensity augmenting-reducing). While augmenting-reducing proved of little benefit, P300 latency was highly correlated with Mini-Mental State (MMS) scores and correctly identified 10 of 18 demented patients. None of the seven patients with psychiatric disorders (primarily depression) or 26 normals were misclassified. Better differentiation of depression and dementia resulted from combined use of P300 latency and MMS scores.
对25名老年患者和26名正常对照者进行了事件相关电位（ERP）记录，以确定ERP是否有助于抑郁症和痴呆症的鉴别诊断。使用了两种ERP测量方法：（1）P300潜伏期，以及（2）对于14分贝音调强度增加（即强度增强-减弱）时N1波幅的增加。虽然强度增强-减弱证明益处不大，但P300潜伏期与简易精神状态检查表（MMS）评分高度相关，并且正确识别出了18名痴呆患者中的10名。7名患有精神疾病（主要是抑郁症）的患者和26名正常对照者均未被误诊。P300潜伏期和MMS评分联合使用能更好地区分抑郁症和痴呆症。
