Neshige R, Barrett G, Shibasaki H
Department of Internal Medicine, Saga Medical School, Japan.
J Neurol Neurosurg Psychiatry. 1988 Sep;51(9):1120-5. doi: 10.1136/jnnp.51.9.1120.
An auditory discrimination paradigm was employed to elicit event-related brain potentials in 13 patients with Alzheimer's disease and 14 patients with multi-infarct dementia. The P300 latency was significantly prolonged in 12 patients with dementia compared with age-matched controls and showed a significant negative correlation with the score of Wechsler Adult Intelligence Scale (WAIS), especially with that of Digit Span subtest. There was no disease specificity. After physostigmine treatment, P300 latency decreased and WAIS score increased in 6 among 10 cases.
采用听觉辨别范式,对13例阿尔茨海默病患者和14例多发梗死性痴呆患者进行事件相关脑电位检测。与年龄匹配的对照组相比,12例痴呆患者的P300潜伏期显著延长,且与韦氏成人智力量表(WAIS)得分呈显著负相关,尤其是与数字广度分测验得分。不存在疾病特异性。在毒扁豆碱治疗后,10例中有6例的P300潜伏期缩短,WAIS得分提高。