Liau M Y, Huang R J, Chen S W
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1982 Nov;15(4):294-9.
As the conventional hyperimmunization schedule in horses introduced by Tanaka could not produce enough neutralizing antibody against Naja naja atra venom, the mixture of Carboxymethyl cellulose (CMC)-Cobra venom incorporated with adjuvant was used for immunization. The neutralizing antibody produced (30 LD50) seemed to be increased but still not to reach the satisfactory level. By using CMC-Cobratoxin adjuvant mixture as an immunizing agent, highly potent antivenin (220 LD50) was obtained.
由于田中提出的马常规超免疫方案无法产生足够的抗眼镜蛇毒中和抗体，因此采用羧甲基纤维素（CMC）-眼镜蛇毒与佐剂混合的制剂进行免疫。所产生的中和抗体（30 LD50）似乎有所增加，但仍未达到令人满意的水平。通过使用CMC-眼镜蛇毒素佐剂混合物作为免疫剂，获得了高效抗蛇毒血清（220 LD50）。
