Mochizuki M, Zigler J S, Russell P, Gery I
Curr Eye Res. 1982;2(9):621-4. doi: 10.3109/02713688208996363.
Lysophosphatidyl choline (LPC), which has been shown to be toxic to the lens in organ culture, is markedly elevated in uveitic eyes. These findings have led to the suggestion that LPC is an initiator of cataractogenesis in uveitis. We report here that a factor not considered by previous investigators, i.e. the presence of serum proteins, can modulate LPC toxicity in vitro. First, the toxicity of LPC to lens epithelial cells or to whole lens in organ culture was effectively neutralized by addition of serum or serum albumin to the test cultures, thus suggesting that the potential toxicity of the increased LPC in the uveitic eye might be neutralized by the concomitant increase in serum protein. Secondly, the susceptibility to LPC toxicity of lens epithelial cells was no greater than that of lymphocytes which are normally exposed to LPC levels higher than those in the uveitic eye.
溶血磷脂酰胆碱（LPC）在器官培养中已被证明对晶状体有毒性，在葡萄膜炎患者的眼中其水平显著升高。这些发现提示LPC是葡萄膜炎中白内障形成的起始因素。我们在此报告，先前研究人员未考虑的一个因素，即血清蛋白的存在，可在体外调节LPC的毒性。首先，通过向测试培养物中添加血清或血清白蛋白，可有效中和LPC对器官培养中的晶状体上皮细胞或整个晶状体的毒性，这表明葡萄膜炎眼中LPC增加所带来的潜在毒性可能会被血清蛋白的相应增加所中和。其次，晶状体上皮细胞对LPC毒性的敏感性并不高于淋巴细胞，而淋巴细胞通常暴露于高于葡萄膜炎眼中LPC的水平。
