Secchi A G
Trans Ophthalmol Soc U K (1962). 1982;102 Pt 3:390-4.
One of the most important components in the pathogenesis of lens opacification related to uveitis appears to be lens permeability changes consisting of potassium loss, sodium and water intake and late leakage of cytoplasmic constituents. These changes may be induced by 'Lens Permeability Factors' present and active in the aqueous humor during inflammation, factors that include antigen-antibody complexes, antilens and antiuveoretinal antibodies, phospholipase A and lysophosphatidylcholine (LPC). The damage caused by at least one of these factors, LPC, may be counteracted in vitro by a monosialoganglioside, (GM1). An in vivo experiment, still in progress, suggests that GM1 has a positive effect even in cases of incipient lens opacification related to uveitis.
与葡萄膜炎相关的晶状体混浊发病机制中最重要的组成部分之一，似乎是晶状体通透性的改变，包括钾离子丢失、钠和水的摄入以及后期细胞质成分的泄漏。这些变化可能由炎症期间房水中存在并起作用的“晶状体通透性因子”诱导，这些因子包括抗原 - 抗体复合物、抗晶状体和抗葡萄膜视网膜抗体、磷脂酶A和溶血磷脂酰胆碱（LPC）。这些因子中至少一种，即LPC所造成的损害，在体外可被单唾液酸神经节苷脂（GM1）抵消。一项仍在进行的体内实验表明，即使在与葡萄膜炎相关的早期晶状体混浊病例中，GM1也有积极作用。
