Cotlier E, Baskin M, Kim J O, Lueck K
Arch Ophthalmol. 1976 Jul;94(7):1159-62. doi: 10.1001/archopht.1976.03910040071013.
In aqueous humor from rabbits with uveitis or after anterior chamber paracentesis, the levels of lysophosphatidyl choline (LPC) were 10.2mug/ml and 14.7mug/ml, respectively. These LPC levels induce early cataractous changes in the rabbit lens in culture. Analysis of the fatty acid composition of LPC showed that saturated fatty acids were more predominant in secondary aqueous humor than in primary aqueous humor. In vitro, natural LPC induced more pronounced gains in sodium ions and water by the lens than similar concentrations of synthetic L-alpha-lysopalmitoyl phosphatidyl choline. In contrast to prostaglandin E, the levels of LPC in aqueous humor of rabbits with uveitis are cataractogenic. Thus, LPC or its precursors, rather than prostaglandins, are involved in the production of cataracts in uveitis.
在患有葡萄膜炎的兔子的房水或前房穿刺后的房水中，溶血磷脂酰胆碱（LPC）的水平分别为10.2微克/毫升和14.7微克/毫升。这些LPC水平在培养的兔晶状体中诱导早期白内障变化。对LPC脂肪酸组成的分析表明，继发性房水中饱和脂肪酸比原发性房水中更占主导地位。在体外，天然LPC比类似浓度的合成L-α-溶血棕榈酰磷脂酰胆碱使晶状体摄取更多的钠离子和水分。与前列腺素E相反，患有葡萄膜炎的兔子房水中的LPC水平具有致白内障作用。因此，LPC或其前体而非前列腺素参与了葡萄膜炎中白内障的形成。
