O'Flaherty E J, Hammond P B, Taylor E
Fundam Appl Toxicol. 1981 May-Jun;1(3):278-81. doi: 10.1016/s0272-0590(81)80128-5.
Renal mechanisms for handling delta-aminolevulinic acid (ALA) were investigated in control and lead-exposed rats infused with ALA at a range of rates which produced plasma ALA as high as 2380 ng/mL. The presence of both reabsorption and secretion mechanisms was demonstrated. Reabsorption is the more efficient of the two mechanisms at low plasma ALA concentrations, and masks secretion in this range. Net secretion is observed at very high plasma ALA concentrations. Exposure to up to 2000 micrograms lead/mL of drinking water for 12 to 18 months had no measurable effect on net ALA excretion at a given plasma ALA level.
在对照大鼠和铅暴露大鼠中研究了处理δ-氨基乙酰丙酸（ALA）的肾脏机制，这些大鼠以一系列速率输注ALA，使血浆ALA高达2380 ng/mL。结果表明同时存在重吸收和分泌机制。在低血浆ALA浓度时，重吸收是两种机制中更有效的一种，并且在该范围内掩盖了分泌。在非常高的血浆ALA浓度下观察到净分泌。暴露于高达2000微克/毫升饮用水中的铅12至18个月，在给定的血浆ALA水平下，对ALA净排泄没有可测量的影响。
