Barański B, Stetkiewicz I, Trzcinka-Ochocka M, Sitarek K, Szymczak W
J Appl Toxicol. 1982 Oct;2(5):255-9. doi: 10.1002/jat.2550020508.
Cadmium chloride was administered by gavage to pregnant rats from day 7 to day 16 of gestation. Cadmium, when administered at a dose of 40 mg Cd per kg per day, was associated with significant maternal toxicity, placental injury and an increased fetal burden of cadmium. At lower dose levels (2-20 mg Cd per kg per day), fetal development was retarded. Teratogenic effects were not observed and the fetal cadmium concentrations did not differ significantly from the controls, despite the marked cadmium accumulation in the placenta and maternal tissues. The body-weight gain during gestation of all cadmium-treated females was reduced and an absolute weight of adrenals in females given cadmium at doses 4 mg kg-1 and higher was significantly increased. The obtained results indicate that cadmium-induced fetal toxicity is associated with concomitant maternal toxicity and alteration in placental function.
在妊娠第7天至第16天，通过灌胃法给怀孕大鼠施用氯化镉。当以每天每千克40毫克镉的剂量施用时，镉与明显的母体毒性、胎盘损伤以及胎儿镉负荷增加有关。在较低剂量水平（每天每千克2 - 20毫克镉）下，胎儿发育迟缓。未观察到致畸作用，尽管胎盘和母体组织中镉明显蓄积，但胎儿镉浓度与对照组相比无显著差异。所有接受镉处理的雌性大鼠在妊娠期的体重增加减少，给予4毫克每千克及更高剂量镉的雌性大鼠肾上腺绝对重量显著增加。所得结果表明，镉诱导的胎儿毒性与伴随的母体毒性和胎盘功能改变有关。
