Barański B
J Hyg Epidemiol Microbiol Immunol. 1984;29(3):253-62.
Cadmium chloride in doses of 2, 12 and 40 mg Cd/kg was administered per os to pregnant rats from the 7th to 16th day of pregnancy. In another experiment female rats were exposed to cadmium oxide at a concentration of 0.02 mg Cd/m3 or 0.16 mg Cd/m3 for 5 hours a day and 5 days weekly for a period of 5 months or 1 mg Cd/m3 for 4 months. The exposure was then continued during mating and from the 1st to 20th day of pregnancy. A decrease in fertility was only observed in females exposed by inhalation to cadmium oxide at a concentration of 1 mg Cd/m3, at which concentration cadmium exhibits a considerable toxic effect on the whole organism. The young of females orally treated with CdCl2 in a dose of 40 mg Cd/kg displayed congenital defects in the form of sirenomelia or amelia, as well as raised cadmium levels in tissues. A retardation of intrauterine development manifested by lower body weight and slowed down osteogenesis was observed in the other groups. A cadmium concentration increase was not found in the tissues of the young in these groups. Inhalation exposure to 0.16 mg Cd/m3 of females prior to and during pregnancy induced in their young a decrease in viability, lower body weight gain, prolongation of latency in the negative-geotaxis test, lower locomotor activity and deteriorated development of the conditioned-reflex response. The offspring of females exposed to 0.02 mg Cd/m3 displayed lowered locomotor activity and worsened consolidation of the conditioned-reflex response.
在妊娠第7天至16天，给怀孕大鼠经口灌胃2、12和40毫克镉/千克剂量的氯化镉。在另一项实验中，雌性大鼠每天暴露于浓度为0.02毫克镉/立方米或0.16毫克镉/立方米的氧化镉环境中，每周暴露5天，每次5小时，持续5个月；或暴露于浓度为1毫克镉/立方米的氧化镉环境中，持续4个月。然后在交配期间以及妊娠第1天至20天继续暴露。仅在吸入浓度为1毫克镉/立方米氧化镉的雌性大鼠中观察到生育力下降，在此浓度下镉对整个机体表现出相当大的毒性作用。经口给予40毫克镉/千克氯化镉的雌性大鼠所产幼崽出现了并腿畸形或无肢畸形等先天性缺陷，且组织中的镉含量升高。在其他组中观察到子宫内发育迟缓，表现为体重降低和成骨减缓。这些组幼崽的组织中未发现镉浓度升高。在妊娠前及妊娠期间吸入0.16毫克镉/立方米氧化镉的雌性大鼠所产幼崽的活力下降、体重增加减少、负趋地性试验潜伏期延长、运动活动减少以及条件反射反应发育恶化。暴露于0.02毫克镉/立方米氧化镉的雌性大鼠的后代运动活动降低，条件反射反应的巩固变差。
