Descotes J, Laschi A, Tachon P, Tedone R, Evreux J C
J Immunopharmacol. 1982;4(4):279-84. doi: 10.3109/08923978209019448.
Administration of diazepam was suggested to exert immuno-suppressive properties in mice. In the present study, we explored the time and dose-dependence of diazepam effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice. DTH response was only depressed when diazepam was injected shortly after immunization and this effect on DTH induction was found with doses of 4 and 8 mg/kg ip while lower doses (0, 5, 1 and 2 mg/kg) remained ineffective.
有人提出给予地西泮对小鼠具有免疫抑制特性。在本研究中，我们探究了地西泮对Balb/c小鼠绵羊红细胞迟发型超敏反应作用的时间和剂量依赖性。仅在免疫后不久注射地西泮时，迟发型超敏反应才受到抑制，并且腹腔注射4和8mg/kg剂量时可发现这种对迟发型超敏反应诱导的作用，而较低剂量（0、5、1和2mg/kg）则无效。
