Descotes J, Tedone R, Evreux J C
J Neuroimmunol. 1985 Jul;9(1-2):81-5. doi: 10.1016/s0165-5728(85)80008-4.
The influence of certain psychotropic drugs on the delayed-type hypersensitivity (DTH) response to sheep red blood cells in BALB/c mice was studied. The effects on the overall response and the induction and elicitation phases were evaluated, using two alternative dosage schedules for each agent. It was found that diazepam had no effect on the DTH reaction but the administration of imipramine, haloperidol, chlorpromazine or meprobramate all resulted in depression of the response, impairing both the induction or elicitation phases. The results indicate that psychotropic drugs may produce in vivo depression of cell-mediated immunity by different mechanisms.
研究了某些精神药物对BALB/c小鼠对绵羊红细胞迟发型超敏反应（DTH）的影响。使用每种药物的两种不同给药方案，评估了对整体反应以及诱导期和激发期的影响。结果发现，地西泮对DTH反应没有影响，但给予丙咪嗪、氟哌啶醇、氯丙嗪或甲丙氨酯均导致反应受到抑制，损害了诱导期或激发期。结果表明，精神药物可能通过不同机制在体内产生细胞介导免疫的抑制作用。
