Frazier J M
Fundam Appl Toxicol. 1981 Nov-Dec;1(6):452-6. doi: 10.1016/s0272-0590(81)80027-9.
Studies of the interaction of zinc and cadmium in the isolated perfused rat liver indicate that excess zinc in the perfusion medium inhibits cadmium uptake by the liver. In order to verify these observations in vivo, the effect of excess zinc on cadmium clearance from plasma in the intact rat was investigated at two cadmium dose levels, 0.15 and 0.30 mg Cd/kg of body weight. Cadmium disappearance from plasma was inhibited by excess zinc in a dose related manner at both cadmium dose levels. Greatest inhibition (55%) of cadmium clearance was attained at a Zn:Cd molar ratio of 17, the highest ratio investigated. Excess zinc in plasma (concentrations in plasma greater than 200 mumole/L) resulted in an increase in the volume of distribution of cadmium. A suggested explanation for this effect was displacement of albumin bound cadmium by excess zinc.
对离体灌注大鼠肝脏中锌与镉相互作用的研究表明，灌注液中过量的锌会抑制肝脏对镉的摄取。为了在体内验证这些观察结果，在两种镉剂量水平（0.15和0.30毫克镉/千克体重）下研究了过量锌对完整大鼠血浆中镉清除的影响。在两种镉剂量水平下，过量的锌均以剂量相关的方式抑制了血浆中镉的消失。在研究的最高锌镉摩尔比为17时，镉清除的最大抑制率（55%）得以实现。血浆中过量的锌（血浆浓度大于200微摩尔/升）导致镉的分布体积增加。对此效应的一种推测性解释是过量的锌取代了与白蛋白结合的镉。
