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人体中表观血铅半衰期对既往铅暴露时长的依赖性。

Dependence of apparent blood lead half-life on the length of previous lead exposure in humans.

作者信息

O'Flaherty E J, Hammond P B, Lerner S I

出版信息

Fundam Appl Toxicol. 1982 Jan-Feb;2(1):49-54. doi: 10.1016/s0272-0590(82)80064-x.

DOI:10.1016/s0272-0590(82)80064-x
PMID:7185602
Abstract

The expected relationship between the apparent half-life of blood lead (PbB) and the length of previous exposure is compared with the observed relationship in a group of workers on strike from a primary smelter where they had been employed for from a few months to ten years. Within this group, the apparent PbB half-life was positively correlated both with pre-strike PbB and with length of exposure to lead. It is likely that the dependence of apparent half-life on pre-strike PbB is primarily a reflection of interindividual differences in lead kinetics in these men. The direct dependence of apparent half-life on duration of lead exposure is consistent with published data from former lead workers and from human subjects experimentally exposed to lead.

摘要

将血铅(PbB)的表观半衰期与之前暴露时长之间的预期关系,与一组来自一家初级冶炼厂的罢工工人的观察结果进行了比较,这些工人在该厂工作了几个月至十年不等。在这个群体中,PbB的表观半衰期与罢工前的血铅水平以及铅暴露时长均呈正相关。表观半衰期对罢工前血铅水平的依赖性,很可能主要反映了这些工人在铅动力学方面的个体差异。表观半衰期对铅暴露时长的直接依赖性,与之前铅作业工人以及实验性暴露于铅的人体受试者的已发表数据一致。

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